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  • 643 Grand Avenue

643 Grand Avenue, South San Francisco, CA 94080

$998,888 Approx. USD 3 beds, 4 baths
1,630 sqft

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Photo of Jesse Hlubik

Jesse Hlubik REALTOR® - Sales Associate 310-890-6928 m
310-890-6928 o
Lic#: 01801928
NRDS ID: 207054480
Jesse@HomeSearchLA.com Text Me
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Lic#: 01801928
NRDS ID: 207054480
Jesse@HomeSearchLA.com Sherman Oaks Office
14141 Ventura Blvd., Ste. 8
Sherman Oaks, CA 91423
Phone: 818-528-3200
Fax: 818-386-9007
 Sherman Oaks 14141 Ventura Blvd., Ste. 8
Sherman Oaks, CA 91423
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Listing Agent


Jill Penna | jill@jillpenna.com
Lic#: 01895080
Broker: Courtesy of Christie's International Real Estate Sereno
Phone: 415-244-8630

Agent Remarks

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Listing Details

Property type: Single Family Residence (Single Family)
Status: Active
MLS# ML82059314
List price is $998,888 Reduced by $249,112 on 9/30/2026
Price: $998,888
Beds: 3
Baths: 4 (4 full)
Built in 1895
1,630 sqft
0.08 acres
Lot size: 0.0803
County: San Mateo
Zoning: RM0000
Appliances: Dishwasher,Disposal,Refrigerator
Heating/cooling: None
Heating description: Central
MLS area: 699 - Not Defined

Last Updated: 10/12/2026

 Days On Market (DOM): 47

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This listing belongs to the 699 - Not Defined MLS area

Lat/Long: 37.657368, -122.421513.
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DISCLAIMER: There is NO WARRANTY, expressed or implied, for the accuracy of this information or its applicability to your financial situation. Please consult your financial and/or tax advisor. GET PRE-APPROVED The loan's interest rate will depend upon the specific characteristics of the loan transaction and credit profile up to the time of closing.

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Photo of Jesse Hlubik

Jesse Hlubik REALTOR® - Sales Associate 310-890-6928 m
310-890-6928 o
Lic#: 01801928
NRDS ID: 207054480
Jesse@HomeSearchLA.com Text Me
Call My Cell
Call My Office
Lic#: 01801928
NRDS ID: 207054480
Jesse@HomeSearchLA.com
Sherman Oaks Office
14141 Ventura Blvd., Ste. 8
Sherman Oaks, CA 91423
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